Corsi di studio in
Farmacia - Chimica e tecnologia farmaceutiche

(1) Understand the state-of-the-art bioinspired nano-engineering technologies and nanomedicines
(2) Be able to critically read, analyze, and interpret the scientific literature in bioinspired nanoengineering and nanomedicines
(3) Apply knowledge of bioinspired nano-engineering and nanomedicines to think critically about possible biomimetic nanoparticle solutions for the development of theranostics
(4) Be able to represent ideas in oral presentations.

1. "Nanomedicines" and "Bioinspired nano-engineering": definition and main categories
2. Site-specific conjugation and multifunctional polymers and main supramolecular conjugates in pharmaceutical use (Protein-polymer conjugates, Drug-protein conjugates, Antibody-drug conjugates Oligonucleotides-polymer conjugates, Drug-polymer conjugates)
3. Systems responsive to internal stimuli: Redox, pH, temperature, enzyme, hypoxia
4. Systems responsive to external stimuli: Magnetic fields, temperature (thermal therapy), ultrasound, light (laser therapy)
5. The importance of adequate physic-chemical characterization in the development of nano-seized systems for pharmaceutical use. 
6. Main methods to define the chemical composition: colorimetric assays, ¹H-NMR Spectroscopy, Infrared and ultraviolet Spectroscopy (FT-IR, UV), Mass Spectrometry, Elemental analysis, Reverse Phase Chromatography (RP-HPLC)
7. Main methods to define the Physico-chemical characteristics: (Hydrodynamic radius (DLS, NTA, MADLS etc), Zeta potential (ELS), Molecular Weight (GPC), Microscopy (AFM, SEM, TEM etc), thermal analysis (DSC, TGA), Diffractometry (XRPD)

The lessons will be held in the classroom.

Students will have to prepare a presentation and summarize a research paper on topics discussed during the lessons.