Corsi di studio in
Farmacia - Chimica e tecnologia farmaceutiche

The course aims to provide students the theoretical and practical basis about the formulation, preparation and control of pharmaceutical forms. Basic knowledge of pharmaceutical legislation relating to the responsibility of the pharmacist in the dispensation of medicinal products, sale of “parafarmaco” and the social function of the community pharmacy are provided.

The course is supplemented by compulsory individual practical laboratory exercises about preparation, quality control, pricing and shipping of pharmaceutical forms most commonly prepared in pharmacy laboratories in accordance with the current legislation.

Oral examination available after passing a written test inherent to the shipment of a medical recipe, at the end of laboratory exercises.

 

Pharmaceutical technology - Drug, medicinal product, excipient, pharmaceutical dosage form. Main administration and excretion routes. Biological membranes. Pharmaceutical, pharmacokinetic and pharmacodynamic phases. Bioavailability and bioequivalence. Factors influencing drug bioavailability.

Main dosage forms in F.U. XII. Technological quality control and assurance assays.

Definition of disperse systems. Inhalation dosage forms and pressurized aerosol. Water in F.U. XII: characteristics, classification, preparation methods, storage and distribution. Hydrophilic and lipophilic solvents. Liquid formulations: solutions, solubility, dissolution rate, colligative properties, isotonic solutions. Disperse systems: characteristics and definitions of emulsions, suspensions, colloids. Liquid dosage forms: solutions, syrups, emulsions, suspensions, extractive formulations (herbal preparation, dried / soft / liquid extracts, tinctures, homeopathic mother tinctures) essential oils. Main administration routes of liquid formulations. Sterility and sterilization: kinetics of microbial degradation; chemical and physical sterilization methods. Parenteral formulations: description, administration route, physico-chemical and biological requirements (solutions, suspensions, emulsions, infusion solutions, TPN). Ophthalmic dosage forms: definition, physico-chemical and biological characteristics. Delayed, sustained and controlled release. Homeopathic medicinal product: history, doctrine, dilutions, preparations, dosage forms. Additives used in pharmaceutical dosage forms: antimicrobial and antioxidant agents, sweeteners, flavours, dyes. Primary and secondary packaging materials and containers.  

 

Pharmaceutical socialeconomics and legislation program– Political system of ItalianState: basic legislative notions. Notices about European legislation. Pharmacist’s penal, civil and administrative responsibility. Italian Pharmacopoeia: historical developing and legal position. European Pharmacopoieia. F.U XII: laws, monographs, tables.  Good galenic preparation law (NBP), DM 18/11/2003, successively modified. New code for human medicinal products: Dlgs 219/2006, successively modified. Label, package leaflet, price tag. Galenics. Generics.New code for veterinary medicinal products: Dlgs 193/2006, successively modified. Patents. Deontological pharmacist code. Galenic Price list (TNM). Doctrine of medicinal products delivery: medical prescription. Delivery of medicinal products without medical prescription: DM 31/03/2008. SOP, OTC. L 248/2006. method applied to elaborate the price list of all categories of medicinal products. Storage and sell out of toxic substances: table 3, FU; “poison register”. Purchase, storage and sell out of narcotic drugs: D.P.R. 309/90, successively modified. Purchase registers, In/Out register for all kind of pharmacy, medical doctor’s supplies. Anti doping doctrine: law in force for galenics and industrial medicines. Special food: HACCP, selfcontrol register in pharmacy. Dlgs 153/09: new services in Pharmacy. Dlgs 332/2000 blood auto-analysis. DGR 67-13974 del 2004: ordinary inspection report. The “parafarmaco”. Pharmaceutical farmacoeconomics and socioecnomics: notices and definition. Pharmaceutical costs: pharmacist’s refund system. Marketing inside pharmacy: notices.

 

practical exercisesin laboratory – these are organized in frontal lessons and exercises of pricelist for galenics -magistral and official-; moreover the galenics delivery is simulated following the law in force. Individual practical exercises, in which are prepared the most common pharmaceutical forms, are performed.

Manual and automatic methods are experimented. Quality assurance (Ph Eur) is checked on galenics individually prepared by students. An informatic management of galenic laboratory is individually applied. Moreover the students are invited to explore the pharmacy on the territory asking some questions about present subjects.

 

 

LABORATORY EXERCISES – including: lessons and exercises of galenic pricing as well as method of delivery of the same, in accordance with the current legislation; individual practical execution of the main pharmaceutical forms dispensable in pharmacy with mechanical and manual method of preparation; quality control of some pharmaceutical forms prepared in the laboratory, according to Eur. Ph.; approach to the most modern computer methods for the computerized management of the pharmacy.  Surveys on current issues into the territory.